Scientist-Sr Scientist - Gene Therapy - in vitro cell modeling | Alabaster, AL

Biosciences is a neuroscience-focused, biomedical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders.

The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis and uterine fibroids, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines

to ease the burden of debilitating diseases and disorders, because you deserve brave science. in collaboration with Abb Vie About the Role: We are looking for a collaborative and highly motivated scientist to join our Research team.

The primary role will be to use cell engineering techniques to generate novel, physiologically relevant cell line/disease models, perform characterization as well as develop cell-based/potency assays to support gene therapy projects. He/she will also be involved in the production and support of more complex, disease relevant primary/i PSC derived cellular models when needed. The ideal candidate must have outstanding written and verbal communication skills,

a strong work ethic, and be able to multitask and prioritize responsibilities.

This candidate will be able to work together with his or her supervisor and the team to seamlessly provide consistent support for drug discovery and development. Your Contributions (include, but are not limited to): This scientist will be an innovative thinker with the ability to work independently, design and carry out experiments and propose creative solutions to challenging problems Provide expertise for cell model development using cell engineering/transfection techniques (Crispr/Cas9), cell culture expansion and differentiation, scale up/down and cell biology/function Provide molecular and cell biology support to execute standard cell culture processes including transfection, selection, sub-cloning, clonal expansion, and banking as well as cell model characterization Design and perform in vitro cell based and potency assays to support Gene Therapy research projects Work in the lab independently and in a collaborative environment with minimal guidance to explore, develop and validate novel models for neurological disorders Help to identify, evaluate, and, where applicable, implement novel methods or technologies that would enhance workflow efficiencies and/or improve the quality of cell model deliverables Requirements: BA/BS in Biochemistry, Biology, bioengineering or a related fields and 7+ years of Biotechnology industry experience including gene therapy-specific techniques and cell model development with emphasis in Neuroscience Ph D degree in relevant discipline and 3+ years as noted above.

Biotech/medical industry experienced preferred Strong experience in developing cell models for neurological diseases, using different immortalized cell lines, neuroblastoma and/or i PSC culture/differentiation into neuronal types and cell clone characterization methods to support gene therapy projects Prior hands-on experience in biochemistry techniques including (but not limited to) q PCR, d PCR, western blot, immunoassays, FACs analysis, protein assay development and data analysis Demonstrated hands on experience with viral (preferably AAV) and/or non-viral gene delivery for gene expression upregulation/downregulation as well as in vitro genome editing Required experience developing new biochemical and cell-based/potency assays Experience using modern automation, LIMS, data analysis and informatics systems is a plus Demonstrated ability to multi-task and be highly productive in a multidisciplinary, fast-paced and diverse environment Ability to work as part of a team; may train other team colleagues Strong communications, problem-solving, analytical thinking skills #LI-AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

The annual base salary we reasonably expect to pay is $103,200.00-$149,700.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.