contributing to the development of future individualized genomic medicines at St. Jude, with room for career growth and advancement. Apply your expertise in high-throughput genomics, cell and molecular biology, or genome editing towards this unique Scientist or Lead Researcher opportunity in the Tsai Genome Editing Lab, focusing on advancing genome editing technologies towards individualized treatments of pediatric patients with bone marrow failures from bench to bedside.
The Tsai lab is a highly collaborative, creative, and fun group of scientists at St. Jude Children's Research Hospital. Our research program centers on: development of state-of-the-art genomic methods for understanding
the global activities of genome editors, protein engineering to improve their capabilities for precise editing, and translation to autologous genome edited hematopoietic stem cell therapies.
Dr. Tsai is co-leading a new Blue Sky Project called PARADIGM (Partnership to Advance Development of Individualized Genomic Medicines) with goal of developing personalized genome editing therapies for St. Jude patients. You would have opportunities to lead exciting projects that include: Protein engineering of improved novel CRISPR base and prime genome editors with human cell-based directed evolution. Developing a platform for high-throughput lead target discovery of precise base and prime editing
targets to correct rare patient-specific mutations. Improving high-throughput methods for understanding the genome-wide activity of genome editors.
You would learn valuable laboratory skills that include: Genome engineering, high-throughput genomics, next-generation sequencing, protein engineering, structural biology, liquid handling automation, hematopoietic stem cell cell culture and transfection, and data science. Project-dependent responsibilities could include: Engineer CRISPR base and prime editors with improved activity and specificities. Test new strategies to edit human hematopoietic stem cells for treatment of bone marrow failure disorders, focused on rapid development of editing strategies for rare patient-specific mutations.
Analyze experimental outcomes and develop high-quality summaries towards manuscripts and grant applications. Draft manuscripts and figures for publication in high-impact journals. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. Preference in genomics, molecular and cell biology. One (1) year or more of hands-on, research laboratory experience preferred. Excellent communication, organizational, and presentation skills preferred. Scientist Minimum Experience: Seven (7) years of relevant post-degree work experience is required Five (5) years of relevant post-degree work experience is required with a Master's degree Three (3) years of relevant post-degree work experience is required with a Ph D Lead Researcher Minimum Experience: Five (5) years of relevant, post-degree work experience is required Two (2) years of relevant post-degree work experience is required with a Master's degree No experience is required with a PHD St.
Jude Benefits St. Jude Children's Research Hospital is one of the world's leading pediatric hospitals whose mission is to advances cures for catastrophic childhood diseases.
Consistent with the vision of our founder, no child is denied treatment based on race, religion, or ability to pay. St. Jude has been consistently named one of the best companies to work for by Fortune, Glass Door, and others. St. Jude offers excellent benefits, great salary, help with relocation, and actively fosters professional development. As part of your role, you will have opportunities to attend and present at national and international meetings such as ASGCT, ASH, Keystone Genome Engineering, CSHL Genome Editing, and FASEB Genome Engineering. Please include your resume and a cover letter addressed to Dr.
Tsai who will read and review all qualified applications. If you have questions about the position, please don't hesitate to e-mail Dr. Tsai directly (). Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St.
Jude.
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